Endocrine Abstracts

Background: The patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk due to the lifelong glucocorticoid therapy and the disease per se.Objective: To evaluate vascular and cardiac function in adults with CAH during optimal corticosteroid and fludrocortisone replacement therapy.Patients and methods: Cross-sectional study of 19 adults with CAH (age 23.7 years ±3.8; males 63%) compared to...

Introduction: Previous studies suggest close relationship between thyroid morphology and the danger of thyroid hormones (THs) disturbances after high single dose of iodine-containing contrast agent. The aim of the study was to assess the prognostic risk factors which influence on THs after the cardiac catheterization at patient with coronary artery disease (CAD).Methods: One hundred twenty patient (F/M=40/80, 59±11 years old) without recognized prev...

Introduction: Left ventricular remodeling (LVR) is the most important consequence of acute myocardial infarction (AMI). The aim of the study was to assess the value of free triiodothyronine (fT3) in the prediction of LVR after AMI and primary coronary angioplasty (PCI).Methods: Seventy patients (F/M=17/53, 61±11 years old) without recognized previous thyroid dysfunction and AMI were enrolled into the prospective observational study. Conventional and...

Late onset hypogonadism (LOH) is common in men with coronary artery disease (CAD) but its interaction with endothelial function and arterial structural changes is debatable.Aim: To investigate whether the LOH in men with CAD predicts endothelial dysfunction.Methods: Two hundred consecutive men with CAD and successful coronary stent implantation or coronary artery bypass grafting were included to the study group (mean age 59±10...

Adiponectin (ADPN), resistin (RSN) and leptin are proteins that affect insulin resistance and atherosclerosis significantly. Although low levels of adiponectin and high levels of resistin and leptin are associated with coronary heart disease and cardiovascular disease risk factors, it is unclear whether adiponectin, resistin and leptin levels are related to the risk of developing ischemic stroke. The aim of the study was to evaluate the adiponectin, resistin and leptin serum l...

Background: Parathyroid carcinoma (PC) is a rare endocrine malignancy affecting 0.5–5% of all patients with primary hyperparathyroidism. Due to the rarity of PC there is still lack of prognostic implications of the disease and clear consensus regarding management. Our purpose was to evaluate prognostic factors and treatment outcomes of patients treated at the Department of Nuclear Medicine and Endocrine Oncology.Methods: The target group covered 44 ...

Autoimmune thyroiditis (AIT) is characterised by infiltration of the thyroid by lymphocytes and other immune cells. Autoantibodies to thyroid-specific antigens: thyroglobulin (TG) and thyroperoxidase (TPO) are also produced. The penetration of inflammatory cells into target organ is regulated by cytokines and adhesion molecules expressed on thyroid endothelial cells. E-selectin is one of the selectin family, and is responsible for interaction between leukocytes and endothelium...

Background: Thyroid hormone deficiency is associated with increased cardiovascular morbidity, which cannot be fully explained by the atherogenic changes in lipid profile observed in these patients. Hyperhomocysteinemia could help to explain the increased risk for arteriosclerotic coronary artery disease in hypothyroidism because is an important and independent risk factor for cardiovascular disease. Hypothyroidism decreases hepatic levels of enzymes involved in the remethylati...